Dr. Pedi Mirdamadi, ND, MS, RHN, IFMCP Leader in Anti-Aging Medicine

Scientific References:

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  • Hongbo Zhang et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352,1436-1443(2016).
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  • Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
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  • Sun, Chongkui, et al. Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. The EMBO Journal. Vol. 39, No. 21. 2 November 2020.
  • Hou, Yujon, et al. NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING. Proceedings of the National Academy of Sciences. Vol. 118, No. 37, September 14, 2021.
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  • Vreones, Michael, et al. Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin. 28 November 2022.
  • Martens, Christopher. Nicotinamide riboside supplementation reduces aortic stiffness and blood pressure in middle-aged and older adults. Artery Research, Volume 20, 2017, Page 49.
  • Denman, B.A., Mazzo, M.R., Martens, C.R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 9, 1286 (2018).
  • Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep (2019) 28(7): 1717-1728.
  • Dolopikou CF, Kourtzidis IA, Margaritelis NV, Vrabas IS, Koidou I et al. Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. Eur J Nutr 6 (2019).
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  • Zhu XH, Lu M, Lee BY, Ugurbil K, Chen W. In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2876-81.
  • Mario Romani, Vincenzo Sorrentino, Chang-Myung Oh, Hao Li, Tanes Imamura de Lima, Hongbo Zhang, Minho Shong, Johan Auwerx. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Reports. 2021; 34 (3):
  • Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
  • Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 Mar 24;355(6331):1312-1317.
  • Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr;62(4):1084-93.
  • Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53.
  • Dingel, Hanna, et al. The state of the U.S. health system in 2022 and the outlook for 2023. Peterson-KFF Health System Tracker. December 22, 2022.
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